生物化学IILectureAminoacidcatabolism23张幻灯片.ppt

生物化学第七章脂类代谢课件.ppt

第七章 脂类代谢 Lipids Metabolism 四川大学华西基础医学与法医学院生物化学与分子生物学教研室傅强 付明德,内 容 提 要脂肪酸及常见脂类的分子组成与结构脂肪动员脂肪酸的氧化酮体的生成利用及生理意义脂肪酸合成的关键酶及其调节,

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1、Amino acid metabolism,Amino acids are not stored like glucose or fatty acidsIe: no polymeric form dedicated for “reserves” of amino acidsOnly muscle provides any real source if not supplemented in dietHumans lost ability to synthesize 10 amino acidsMost of them require complex pathways, lots of ener。

科学探究专题复习(化学展示课)讲解课件.ppt

化学科学探究专题解析,科学的核心是探究。科学探究是学习科学的一种重要方法。科学探究也是现行教材和中考中的一个重要组成部分。,科学探究的重要性,1.知道科学探究的基本要素，了解科学探究的常见题型，掌握科学探究解题规律。2.能自主地进行探究， ,

2、gy, lots of enzymesWhy cant we synthesize them? Evolutionary advantage?Excess amino acids cannot be stored and therefore are broken downGlycolysis/TCA cycle intermediates,Amino acid oxidation,Amino acids large source of energyDepending on animal can be as much as 90% (carnivores)Essentially 2 pathwa。

3、ys to consider when breaking down amino acids:Fate of amino groupFate of carbon skeleton,Transamination and Deamination,Example of transamination Glutamate is always involved in transamination (aminotransferase) reactions.Many types of transaminases that are specific for a certain amino acidCoenzyme。

4、 PLP (pyridoxal phosphate (Vit B6) is required by all transaminases,Transamination and deaminations involved in removal of amino group from an amino acid,PLP,Pyridoxal phosphate,Cofactor for all transaminase reactionsActs to transfer an amino group from an amino acid to a keto-acid,Attaches to a lys。

5、ine residue on the transaminase enzyme,Pyridoxal phosphate rxn mechanism for transaminases,NH4 transport and deamination,The oxidation of amino acids leads to a buildup of glutamate (acceptor of NH3)Glutamine serves as the principle carrier (non-toxic) of excess NH4 in the bloodTransported to liver 。

6、(mitochondria) where it is processed: NH4 is removedGlu Dehase is an example of oxidative deamination,(blood),Liver,Alanine as secondary NH4 carrier,Alanine serves to transport NH4 from the muscle to the liverFormed by ala transaminase (seen previously) with glu as the NH4 donorReverse reaction happens in the liver where NH4 is “dropped off” back onto -KG.,Oxidation of amino acids, review,Special deamination mechanism for serine and aspartate,Some amino acids have their own way to shed NH4,NH3 f。